Table II.
Relative Strand Break Probabilities. Analysis of the frequency of strand break of GGG regions (normalized against the frequency of all strand breaks within the substrate) compared with the strand break frequency of analogous triplets normalized using the same treatment. Analysis indicates a reduction in strand break occurrence for GGG regions when compared to their analogues with identical flanking base identity.
Oligonucleotide | Triplet Sequence | Strand Break Probability |
---|---|---|
AAGAC | 0.147 ± 0.0056 | |
Single-G | ACGCT | 0.117 ± 0.0071 |
CTGTA | 0.086 ± 0.0109 | |
AGGGA | 0.105 ± 0.0151 | |
Triple-G | CGGGC | 0.096 ± 0.0117 |
TGGGT | 0.063 ± 0.0064 |