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. Author manuscript; available in PMC: 2016 Nov 6.
Published in final edited form as: Leukemia. 2016 May 6;30(11):2221–2231. doi: 10.1038/leu.2016.107

Figure 1. Mesenchymal stem cell-derived EVs reverse radiation damage to marrow stem cells.

Figure 1

(A) Schematic diagram of the reversal of radiation injury to marrow stem cells 7 days after irradiation. (B) Effect of murine MSC-EVs on engraftment capacity of irradiated mouse marrow cells over time post cell infusion. The percentage of engraftment (donor chimerism) was calculated as the ratio of CD45.1 (donor) cells to CD45.1 plus CD45.2. Data are expressed as a mean ± SEM, N=5/group. (C) Vesicle effects on secondary engraftment. Data are expressed as a mean ± SEM, N=6/group.