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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Structure. 2016 Sep 22;24(11):1898–1906. doi: 10.1016/j.str.2016.08.011

Figure 5. A proposed mechanism of the regulation of dimer-monomer equilibrium in SOD1 by post-translational modifications.

Figure 5

T2-Phosphorylation and C-111 glutathionylation may regulate the dimer-monomer equilibrium and have opposing effects on the stability of native SOD1 dimers. The T2D mutation (or T2-Phosphorylation) inhibits the dimer dissociation (decreased koff), whereas C111-glutathionylation inhibits the association of monomers (decreased kon).