Table 1.
Association between body mass index (BMI) and endometrial cancer risk overall, and for endometrioid and non-endometrioid histologies1
| Controls | All cases | Endometrioid cases | Non-endometrioid cases | ||||
|---|---|---|---|---|---|---|---|
| BMI2 Category |
N (%) | N (%) | OR (95% CIs) | N (%) | OR (95% CIs) | N (%) | OR (95% CIs) |
| <25kg/m2 | 7146 (45%) | 1159 (28%) | Reference | 964 (28%) | Reference | 195 (32%) | Reference |
| 25–29.9 | 5628 (35%) | 1252 (31%) | 1.06 (0.65–1.70) | 1053 (30%) | 1.05 (0.64–1.72) | 199 (33%) | 1.27 (1.07–1.48) |
| 30–34.9 | 2213 (14%) | 795 (19%) | 1.60 (0.95–2.71) | 684 (20%) | 1.62 (0.94–2.80) | 111 (18%) | 1.88 (1.64–2.12) |
| 35–39.9 | 693 (4%) | 472 (12%) | 3.522(2.35–4.43) | 413 (12%) | 3.26 (2.31–4.61) | 59 (10%) | 3.16 (2.85–3.48) |
| ≥40 | 294 (2%) | 409 (10%) | 6.10 (3.67–10.17) | 366 (10%) | 6.26 (3.55–11.06) | 43 (7%) | 5.92 (5.56–6.27) |
| Ptrend3 | 1.8×10−26 | 1.7×10−17 | 1.42×10−27 | ||||
| Per 5kg/m2 increase in EC risk |
1.55 (1.44–1.68) | 1.56 (1.42–1.72) | 1.50 (1.43–1.57) | ||||
1
Random effects model.
2
BMI range: Overall 15.24–75.00 (mean 27.18, SD 5.72); Cases 15.24–75.00 (mean 29.86, SD 7.45)’ Controls 15.94–67.90 (mean 26.52, SD 4.99).
3
Tests for heterogeneity: All cases I2=73.4%, Q=7.53, P=0.02; Endometrioid cases I2=81.1%, Q=10.57, P=0.005. Non-endometrioid cases are from the iCOGs dataset only and were not meta-analyzed.