Table 3.
Association of the 34- and 47-SNP waist-hip ratio weighted genetic risk score (WHRwGRS) with endometrial cancer risk
| 34-SNP wGRS | 47-SNP wGRS | |||
|---|---|---|---|---|
| WHRwGRS1 Quartiles |
Odds Ratio (95% CI) | P-value | Odds Ratio (95% CI) | P-value |
| Q1 | Reference | Reference | ||
| Q2 | 1.00 (0.96–1.03) | 9.5×10−1 | 0.99 (0.96–1.02) | 4.5×10–1 |
| Q3 | 0.98 (0.96–0.01) | 7.0×10–2 | 098 (0.94–0.01) | 2.6×10–1 |
| Q4 | 0.99 (0.97–0.01) | 3.2×10–1 | 0.98 (0.95–0.01) | 1.3×10–1 |
| Per wGRS quartile increase in EC risk |
0.99 (0.99–1.00) | 1.7×10–1 | 0.99 (0.99–1.00) | 2.4×10–1 |
| wGRS as a continuous variable |
1.02 (0.99–1.04) | 9.0×10–2 | 0.97 (0.63–1.31) | 8.6×10–1 |
1
Range 34 SNP WHRwGRS: Overall 0.53–1.52 (mean 0.98, SD 0.12); Cases 0.57–1.36 (mean 0.98, SD 0.12); Controls 0.53–1.52 (mean 0.98, SD 0.12). Range 47 SNP WHRwGRS: Overall 0.67–1.76 (mean 1.21, SD 0.14): Cases 0.67–1.69 (mean 1.22, SD 0.14); Controls 0.68–1.76 (mean 1.20, SD 0.14).