Table 3.
Multivariate models using ICU death as a dependent variable and Sepsis-3 definition, lactate, age, SAPS 3 and requirement for RRT and mechanical ventilation as independent variables
| Lactate as a continuous variable | Lactate > 2 mmol/L | Lactate > 4 mmol/L | ||||
|---|---|---|---|---|---|---|
| OR (CI 95%) | P value | OR (CI 95%) | P value | OR (CI 95%) | P value | |
| Sepsis-3 model | ||||||
| No-dysfunction | 1 | Reference | 1 | Reference | 1 | Reference |
| Sepsis | 3.70 (1.75–9.12) | 0.002 | 3.35 (1.57–8.27) | 0.004 | 3.67 (1.73–9.07) | 0.002 |
| Septic shock | 6.21 (2.94–15.27) | <0.001 | 7.31 (3.41–18.22) | <0.001 | 6.22 (2.94–15.31) | <0.001 |
| Lactate | 1.11 (1.06–1.16) | <0.001 | 0.94 (0.60–1.48) | 0.811 | 2.28 (1.61–3.24) | <0.001 |
| Age | 1.01 (1.01–1.02) | <0.001 | 1.01 (1.01–1.02) | 0.002 | 1.01 (1.00–1.02) | <0.001 |
| SAPS 3 | 1.02 (1.01–1.03) | <0.001 | 1.02 (1.01–1.03) | <0.001 | 1.02 (1.01–1.03) | <0.001 |
| RRTa | 1.63 (1.15–2.31) | 0.006 | 1.56 (1.11–2.21) | 0.011 | 1.66 (1.17–2.36) | 0.004 |
| Mechanical ventilationa | 1.29 (0.95–1.76) | 0.107 | 1.26 (0.92–1.71) | 0.146 | 1.27 (0.93–1.73) | 0.131 |
| AUCb
(CI 95%) |
Asymptotic P value |
AUCb
(CI 95%) |
Asymptotic P value |
AUCb
(CI 95%) |
Asymptotic P value |
|
|---|---|---|---|---|---|---|
| Model accuracy | 0.732 (0.698–0.766) | <0.001 | 0.725 (0.691–0.759) | <0.001 | 0.732 (0.698–0.766) | <0.001 |
aSupport needed at any time of ICU stay; RRT renal replacement therapy; SAPS Simplified Acute Physiological Score
bAUC area under the curve