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. 2016 Nov 3;8:35. doi: 10.3389/fnsyn.2016.00035

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Copyright © 2016 Hoxha, Tempia, Lippiello and Miniaci.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of spino-cerebellar ataxias (SCA) affecting the PF-PC synapse. In SCA1 and SCA5, the mGlu₁ receptor is dysregulated. In SCA3 the endocannabinoid-dependent suppression of excitation evoked by PF stimulation is absent. Since this response requires mGlu₁ activation, it has been hypothesized that signaling through this receptor is impaired. In SCA27 the release of glutamate by PFs is deficient.