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MBL-mediated complement activation in the absence of the classical pathway. A. fumigatus (1 × 107 conidia/ml) was added into C1q-deficient serum plus ficolin-2 inhibitor, MBL inhibitor, or MBL mock-inhibitor. Complement products were measured by flow cytometry and expressed as mean fluorescence intensity (MFI): (A) C4b, (B) C3b, and (C) TCC. Results represent the means of three independent experiments ± SD, *p ≤ 0.05 (one-way ANOVA, Bonferroni’s multiple comparison test).
