FIGURE 8.

Gene alignment and biosynthesis pathway of hevein-like peptides. (A) Precursor sequences alignment of ginkgotides, hevein, and hevein-like peptides. The precursors are divided into three major domains, including the signal peptide, mature hevein-like peptide domain and C-terminal tail. (B) Comparison of the biosynthesis pathways between ginkgotides and other hevein-like peptides. Signal peptide was removed from the full precursor sequences by SPase. The C-terminal tail is then cleaved by endopeptidase to release the mature peptides. In 8C- (except ginkgotides) and 10C-hevein-like peptides, the C-terminal tail was coded for a bio-functional protein such as barwin-like protein or chitinase. ^∗ Represents the stop codon.