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. 2016 Nov 3;10:494. doi: 10.3389/fnins.2016.00494

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Copyright © 2016 Wilson, Smith, Inman, Dengler-Crish and Crish.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amyloid-β₄₂ elevations provide an early retinal marker of pathology and are later observed in the distal projection. (A) Retinal Aβ₄₂ was elevated in all DBA/2J age groups compared to controls (left), with no transport-dependent effects observed (right). (B) However, collicular elevations appeared later, with 8–10 and 12–15 month DBA/2J SC having significantly elevated levels compared to controls; a significant difference was also observed between 3–5 and 8–10 month DBA/2Js (left). Levels of Aβ₄₂ were significantly elevated in SC lacking intact transport (CTB-) compared to transport-intact (CTB+) SC (right). Error bars indicate SEM. Asterisk indicates that groups are significantly different from bracketed comparison (p <0.05).