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Pharmacokinetic Parameters for IV-injected 10 nmol/kg Insulin Lispro and BIL in 5/6-nephrectomized Sprague–Dawley Rats
| Mean (SEM) | Insulin Lispro | BIL | ||
|---|---|---|---|---|
| Model | 5/6 | Sham | 5/6 | Sham |
| C0 (nM) | 184 (38) | 123 (31) | 295 (22) | 239 (22) |
| AUC0-∞ (nM × hour) | 15 (1.4) | 4 (0.5) | 305 (16) | 287 (19) |
| CL (L/hour/kg) | 0.67 (0.064) | 2.24 (0.262) | 0.033 (0.0017) | 0.035 (0.0023) |
| Vdss (L/kg) | 0.13 (0.022) | 0.42 (0.087) | 0.050 (0.004) | 0.059 (0.007) |
