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Pharmacokinetic Parameters in Serum After IV Administration of BIL to non-LDC Sheep
| Parameter | BIL (Mean ± SD) | ||
|---|---|---|---|
| Number (N) | 3 | 4 | 3 |
| Dose (nmol) | 20 | 40 | 120 |
| AUC0-t (pM × hours) | 12566.7 ± 1800.9 | 40075.0 ± 12458.3 | 111666.7 ± 15044.4 |
| T1/2 (hours) | 1.6 ± 0.1 | 2.8 ± 0.3 | 3.3 ± 1.2 |
| CL (mL/min/kg) | 0.70 ± 0.09 | 0.53 ± 0.21 | 0.47 ± 0.06 |
| Vdss (L/kg) | 0.05 ± 0.01 | 0.04 ± 0.01 | 0.07 ± 0.04 |
| C0 (pM) | 11133 ± 1234 | 27900 ± 6124 | 60400 ± 1039 |
