Table IV.
Pharmacokinetic Parameters in Serum After Administration of 120-nmol BIL to Sheep
| Parameter (Units) | BIL (Mean ± SD) | |||
|---|---|---|---|---|
| Number (N) | 4 | 5 | 4 | 3 |
| Route | SC (LDC) | SC (non-LDC) | IV (LDC) | IV (non-LDC) |
| AUC0-t (pM × hours) | 2594.5 ± 2563.6 | 142960.0 ± 83820.7 | 139500.0 ± 60693.2 | 111666.7 ± 15044.4 |
| T1/2 (hours) | 4.6 ± 4.0a | 7.5 ± 5.1 | 5.7 ± 2.1 | 3.3 ± 1.2 |
| CL (mL/min/kg) | NA | NA | 0.37 ± 0.12 | 0.47 ± 0.06 |
| Vdss (L/kg) | NA | NA | 0.04 ± 0.01 | 0.07 ± 0.04 |
| C0 (pM) | NA | NA | 70175.0 ± 13600.1 | 60400 ± 1039.2 |
| Tmax (hours) | 2.3 ± 1.0 | 2.4 ± 0.9 | NA | NA |
| Cmax (pM) | 415.3 ± 384.0 | 18766.0 ± 7833.3 | NA | NA |
| % bioavailability | 1.7 | 123 | NA | NA |
| AUCLDC/AUCintact | 0.018 | 1.25 | ||
a N = 3