Table 3.

Iron status parameters in female and male of control and H63D mutation groups

Variables	WT_F (n = 21)	WT_M (n = 39)	H63D_F (n = 27)	H63D_M (n = 31)
Fe (ug/dl)	93.9 ± 26.8	104.4 ± 33.9	134.0 ± 52.6a	167.9 ± 52.0b,c
Ferritin (ng/ml)	28.7 ± 16.2	27.8 ± 15.6	32.7 ± 19.8	42.1 ± 23.7
Ts (%)	27.1 ± 7.83	27.0 ± 8.93	36.8 ± 15.0	44.7 ± 16.6b,c
Hb (g/dl)	13.4 ± 0.74	14.2 ± 1.08	13.9 ± 0.90d	15.7 ± 1.43b,c
RBC (ml/dl)	4.68 ± 0.35	5.05 ± 0.33e	4.73 ± 0.47d	5.30 ± 0.41b
Ht (%)	39.6 ± 2.08	41.5 ± 3.04	43.3 ± 10.8	45.4 ± 3.72b
TIBC	266.9 ± 7.5	279.8 ± 43.6	134.0 ± 52.6f,a	167.9 ± 52.0b,c

Results are shown as means ± SD

WT_F wild type female, WT_M wild type male, H63D_F H63D female, H63D_M H63D male, Fe iron, Ts transferrin saturation, Hb hemoglobin concentration, RBC red blood cells, Ht hematocrit, TIBC total iron-binding capacity

Statistical significant difference:

Fe; ^aH63D_F/WT_F, p = 0.0320; ^bH63D_M/WT_F, p = 0.0002; ^cH63D_M/WT_M, p = 0.0002

Ts; ^bH63D_M/WT_F, p = 0.0004; ^cH63D_M/WT_M, p = 0.0004

Hb; ^dH63D_F/H63D_M, p = 0.0002; ^bH63D_M/WT_F, p = 0.0001; ^cH63D_M/WT_M, p = 0.0006

RBC; ^dH63D_F/H63D_M, p = 0.0005; ^bH63D_M/WT_F, p = 0.0002; ^eWT_F/WT_M, p = 0.0048

Ht; ^bH63D_M/WT_F, p = 0.0124

TIBC; ^fH63D_F/WT_M, p = 0.0001; ^aH63D_F/WT_F, p = 0.0001; ^bH63D_M/WT_F, p = 0.0001; ^cH63D_M/WT_M, p = 0.0001