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. 2016 Oct 25;7:13053. doi: 10.1038/ncomms13053

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Schematic representation of the R26-Confetti;R26-CreERT2 mouse model. (b) Initial labelling level observed 2 days after the administration of a single, low-dose of tamoxifen (1 mg intraperitoneal (i.p.)) to 4-week-old mice. Scale bar, 100 μm. (c) Labelling patterns observed in R26-Confetti;R26-CreERT2 pubertal mice confirm the results from the R26^[CA]30 model. Labelling was induced by the administration of a single, low-dose of tamoxifen (1 mg i.p.) to 4-week-old mice and mammary glands were collected after a 3-week chase. Left panel shows a region containing YFP⁺ luminal cells and RFP⁺ basal cells (arrowhead) populating three branches, interspersed with unlabelled cells. Right panel shows a region containing GFP⁺, YFP⁺ and RFP⁺ luminal cells in a single branch. Scale bar, 100 μm (overview) and 50 μm (inset). Images are representative of three mice. Additional images are shown in Supplementary Fig. 11.