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. 2016 Oct 25;7:13157. doi: 10.1038/ncomms13157

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Copyright © 2016, The Author(s)

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(a) Canonical role of Yen1 in the resolution of HR intermediates that arise during HR-mediated recovery of stalled replication forks. Mus81-Mms4 is activated by hyperphosphorylation in G2/M, prior to activation and nuclear import of Yen1 upon anaphase onset. Thus, HR intermediates are predominantly cleaved by Mus81-Mms4, with Yen1 acting as a catchall in M phase to remove persistent recombination structures in time for chromosome segregation. (b) Parallel to HR, the Dna2 helicase is tending to stalled replication forks. Replication intermediates that escape the attention of Dna2 give rise to toxic structures that are sensed by the DNA damage checkpoint, but which are refractory to processing by Mus81-Mms4. At anaphase entry, Yen1 is activated and uniquely resolves persistent replication intermediates, averting mitotic catastrophe. See text for details.