. 2016 Nov 3;6:36264. doi: 10.1038/srep36264

Table 3. Stratified analysis for associations between genetic polymorphisms in homocysteine removal genes and PCa risk by recessive genetic model in Han Chinese men.

Variables	rs28372871 (cases/controls)		Adjusted OR^a (95% CI)	P	P^hom	rs1131450 (cases/controls)		Adjusted OR^a (95% CI)		P	P^hom	rs1805087 (cases/controls)		Adjusted OR^a (95% CI)	P	P^hom
Variables	TT/TG	GG	Adjusted OR^a (95% CI)	P	P^hom	GG/GA	AA	AA/AG	GG	P	P^hom			Adjusted OR^a (95% CI)	P	P^hom
Age (yr), median
≤68	762/1031	253/274	1.21 (0.95–1.53)	0.120	0.294	959/1260	56/45	1.77 (1.08–2.88)		0.022	0.970	1006/1293	9/12	0.81 (0.29–2.23)	0.680	0.115
>68	597/585	205/136	1.42 (1.04–1.96)	0.028		750/692	52/29	1.53 (0.81–2.88)		0.180		791/718	11/3	3.14 (0.73–13.49)	0.110
BMI (kg/m2)
＜25	993/1166	315/297	1.22 (0.92–1.51)	0.074	0.193	1233/1410	75/53	1.49 (0.99–2.22)		0.053	0.768	1292/1452	16/11	1.79 (0.0.79–4.10)	0.160	0.631
≥25	366/450	143/113	1.47 (1.07–2.01)	0.016		476/542	33/21	1.83 (0.97–3.45)		0.061		505/559	4/4	1.30 (0.29–5.89)	0.730
Hypertension
No	801/954	253/247	1.14 (0.91–1.43)	0.250	0.199	994/1160	60/41	1.51 (0.95–2.42)		0.081	0.851	1045/1190	9/11	1.06 (0.39–2.87)	0.920	0.113
Yes	558/662	205/163	1.45 (1.11–1.90)	0.006		715/792	48/33	1.50 (0.88–2.57)		0.140		752/821	11/4	4.17 (1.10–15.83)	0.026
Diabetes mellitus
No	1224/1463	412/363	1.35 (1.13–1.61)	9 × 10⁻⁴	0.425	1539/1760	97/66	1.55 (1.08–2.21)		0.017	0.875	1620/1812	16/14	1.49 (0.69–3.23)	0.320	0.997
Yes	135/153	46/47	0.86 (0.48–1.54)	0.620		170/192	11/8	2.38 (0.82–6.87)		0.110		177/199	4/1	4.20 (0.27–64.20)	0.290
Cardiovascular disease
No	1254/1467	406/375	1.21 (0.92–1.46)	0.067	0.055	1558/1779	101/63	1.80 (1.26–2.58)		0.001	0.078	1646/1827	14/15	1.10 (0.50–2.44)	0.810	0.061
Yes	105/149	52/35	2.32 (1.26–4.25)	0.006		151/173	7/11	0.37 (0.10–1.36)		0.120		151/184	6/0	NA (0.00-NA)	0.005
Gleason score
≤7	932/1616	280/410	1.13 (0.93–1.38)	0.220	0.017	1153/1952	59/74	1.10 (0.73–1.66)		0.660	0.037	1204/2011	8/15	1.05 (0.41–2.71)	0.910	0.057
≥8	427/1616	178/410	1.67 (1.31–2.14)	<0.0001		556/1952	49/74	2.83 (1.78–4.48)		<0.0001		593/2011	12/15	2.79 (1.13–6.87)	0.028
Extracapsular extension
No	961/1616	270/410	1.03 (0.84–1.25)	0.780	<0.0001	1171/1952	60/74	1.20 (0.81–1.79)		0.370	0.033	1218/2011	13/15	1.42 (0.64–3.17)	0.390	0.835
Yes	398/1616	188/410	2.08 (1.62–2.67)	<0.0001		538/1952	48/74	2.41 (1.51–3.87)		3 × 10⁻⁴		579/2011	7/15	2.63 (0.86–8.05)	0.099
Seminal vesicle invasion
No	1074/1616	317/410	1.11 (0.92–1.34)	0.260	<0.0001	1321/1952	70/74	1.22 (0.83–1.79)		0.310	0.022	1375/2011	16/15	1.78 (0.83–3.82)	0.140	0.761
Yes	285/1616	141/410	2.12 (1.60–2.82)	<0.001		388/1952	38/74	3.08 (1.83–5.18)		<0.0001		422/2011	4/15	1.51 (0.39–5.89)	0.560
Positive surgical margin
No	1094/1616	371/410	1.29 (1.08–1.54)	0.006	0.837	1383/1952	82/74	1.51 (1.05–2.16)		0.026	0.300	1450/2011	15/15	1.43 (0.67–3.09)	0.360	0.601
Yes	265/1616	87/410	1.29 (0.93–1.81)	0.140		326/1952	26/74	1.79 (0.95–3.36)		0.078		347/2011	5/15	3.09 (0.81–11.71)	0.110
Lymph node involvement
No	1259/1616	404/410	1.23 (1.04–1.47)	0.017	0.007	1569/1952	94/74	1.45 (1.02–2.05)		0.039	0.133	1644/2011	19/15	1.75 (0.85–3.64)	0.130	0.198
Yes	100/1616	54/410	1.96 (1.27–3.02)	0.003		140/1952	14/74	3.02 (1.39–6.57)		0.008		153/2011	1/15	1.93 (0.18–21.10)	0.610
Variables	rs326119 (cases/controls)		Adjusted OR^a (95% CI)	P	*Phom*	rs1801394 (cases/controls)		Adjusted OR^a (95% CI)		P	*Phom*	rs2850144 (cases/controls)		Adjusted OR^a (95% CI)	P	*Phom*
Variables	AA/AC	CC	Adjusted OR^a (95% CI)	P	*Phom*	AA/AG	GG	CC/CG	GG	P	*Phom*			Adjusted OR^a (95% CI)	P	*Phom*
Age (yr), median
≤68	925/1181	90/124	0.93 (0.70–1.23)	0.600	0.701	938/1205	77/100	0.99 (0.73–1.35)		0.940	0.894	888/1140	127/165	0.99 (0.77–1.27)	0.920	0.593
>68	728/644	74/77	0.82 (0.53–1.26)	0.360		753/675	49/46	1.07 (0.63–1.80)		0.810		689/609	113/112	0.91 (0.64–1.30)	0.610
BMI (kg/m2)
＜25	1190/1319	118/144	0.89 (0.68–1.18)	0.430	0.905	1215/1365	93/98	1.07 (0.78–1.48)		0.660	0.197	1146/1275	162/188	0.92 (0.72–1.18)	0.530	0.979
≥25	463/506	46/57	0.91 (0.57–1.43)	0.670		476/515	33/48	0.70 (0.42–1.16)		0.160		431/474	78/89	1.07 (0.74–1.54)	0.710
Hypertension
No	959/1067	95/134	0.77 (0.56–1.05)	0.096	0.195	977/1122	77/79	1.17 (0.81–1.68)		0.400	0.153	907/1033	147/168	0.96 (0.73–1.26)	0.780	0.647
Yes	694/758	67/69	1.30 (0.88–1.94)	0.190		714/758	49/67	0.74 (0.47–1.18)		0.200		670/716	93/109	0.95 (0.67–1.35)	0.790
Diabetes mellitus
No	1481/1641	155/185	0.92 (0.72–1.18)	0.530	0.330	1519/1695	117/131	0.98 (0.74–1.31)		0.910	0.339	1421/1573	215/253	0.93 (0.75–1.16)	0.530	0.489
Yes	172/184	9/16	0.33 (0.10–1.15)	0.064		172/185	9/15	0.59 (0.20–1.74)		0.330		156/176	25/24	1.66 (0.81–3.38)	0.170
Cardiovascular disease
No	1512/1654	148/188	0.85 (0.66–1.09)	0.200	0.177	1543/1712	117/130	0.99 (0.74–1.32)		0.950	0.322	1441/1595	219/247	1.00 (0.80–1.24)	0.990	0.509
Yes	141/171	16/13	1.91 (0.73–4.99)	0.190		148/168	9/16	0.52 (0.17–1.54)		0.220		136/154	21/30	1.18 (0.55–2.50)	0.670
Gleason score
≤7	1104/1825	108/201	0.97 (0.74–1.29)	0.850	0.836	1126/1880	86/146	0.99 (0.72–1.36)		0.970	0.744	1058/1749	154/277	0.90 (0.71–1.14)	0.390	0.449
≥8	549/1825	56/201	0.80 (0.55–1.16)	0.230		565/1880	40/146	0.87 (0.57–1.34)		0.530		519/1749	86/277	1.09 (0.80–1.49)	0.570
Extracapsular extension
No	1129/1825	102/201	0.83 (0.63–1.10)	0.190	0.176	1146/1880	85/146	0.91 (0.67–1.25)		0.570	0.951	1069/1749	162/277	0.95 (0.75–1.21)	0.680	0.940
Yes	524/1825	62/201	1.11 (0.78–1.59)	0.560		545/1880	41/146	1.01 (0.66–1.55)		0.970		508/1749	78/277	0.96 (0.70–1.32)	0.810
Seminal vesicle invasion
No	1271/1825	120/201	0.89 (0.68–1.16)	0.370	0.351	1297/1880	94/146	0.92 (0.68–1.24)		0.590	0.642	1208/1749	183/277	0.95 (0.76–1.19)	0.650	0.917
Yes	382/1825	44/201	1.00 (0.66–1.52)	1.000		394/1880	32/146	1.05 (0.65–1.72)		0.830		369/1749	57/277	0.99 (0.69–1.42)	0.940
Positive surgical margin
No	1339/1825	126/201	0.84 (0.65–1.09)	0.200	0.257	1366/1880	99/146	0.89 (0.66–1.19)		0.410	0.594	1266/1749	199/277	0.98 (0.79–1.21)	0.830	0.389
Yes	314/1825	38/201	1.13 (0.71–1.79)	0.600		325/1880	27/146	1.28 (0.72–2.26)		0.410		311/1749	41/277	0.89 (0.58–1.36)	0.580
Lymph node involvement
No	1519/1825	144/201	0.86 (0.67–1.11)	0.240	0.100	1551/1880	112/146	0.91 (0.68–1.20)		0.500	0.310	1443/1749	220/277	0.98 (0.80–1.21)	0.870	0.936
Yes	134/1825	20/201	1.23 (0.66–2.26)	0.520		140/1880	14/146	1.51 (0.75–3.06)		0.260		134/1749	20/277	0.97 (0.54–1.74)	0.930

OR, odds ratio; 95% CI, 95% confidence interval.

^homP value for homogeneity test using the χ²-based Q-test.

^aAdjusted for age, BMI, hypertension, diabetes mellitus, and cardiovascular disease in multivariant logistic regression models.