TABLE 1.
Outcome Measures Derived from MA1 and SRTM Analysis of 18F-PF-05270430 Imaging Data in Rhesus Monkeys
|
BPND |
||||||
| MA1 VT (mL/cm3) |
MA1 |
SRTM |
||||
| Region | Mean | COV | Mean | COV | Mean | COV |
| Cerebellum | 1.28 | 6% | 0 | — | 0 | — |
| Occipital cortex | 1.34 | 4% | 0.05 | 50% | 0.06* | 33%* |
| Temporal cortex | 1.59 | 2% | 0.25 | 24% | 0.25 | 29% |
| Cingulate cortex | 1.82 | 5% | 0.42 | 6% | 0.44 | 8% |
| Frontal cortex | 1.93 | 5% | 0.51 | 18% | 0.50 | 20% |
| Caudate | 3.23 | 3% | 1.54 | 12% | 1.56 | 12% |
| Nucleus accumbens | 3.42 | 5% | 1.68 | 12% | 1.69 | 13% |
| Putamen | 3.71 | 3% | 1.92 | 13% | 1.96 | 14% |
*
Mean and COV of BPND (SRTM) in occipital cortex calculated from one monkey (BM090, n = 2), because estimates in TM762 were unstable (relative SE > 100%).
Values of VT and BPND averaged across 4 scans in 2 subjects.