Fig. 3.

The Proteostasis Network. The pathway for protein synthesis and maturation is shown with specific cellular processes indicated with blue arrows and pathway intermediates indicated in circles. The functional categories of proteins that have been identified as members of the proteostasis network are shown in boxes, with → representing positive regulation and —| representing negative regulation. The thick arrow for on-pathway folding represents the fact that for most proteins under normal non-stress conditions, on-pathway folding predominates over off-pathway folding