Table 2.
Characteristics of putative G-quadruplex-forming sequences in the P. falciparum 3D7 genome
PQS group | Total # PQSs in group | # PQSs with total loop length ≤7 | # of 1 or 2 nucleotide loops | # single pyrimidine (not purine) loops | # PQSs with a longest-central loop | |
---|---|---|---|---|---|---|
1 nt | 2 nt | |||||
Var-associated | 35 | 2 (5.7 %) | 4 (3.8 %) | 4 (3.8 %) | 4 (3.8 %) | 23 (65.7 %) |
Non-var-associated | 45 | 13 (28.9 %) | 23 (17.0 %) | 18 (13.3 %) | 2 (1.5 %) | 9 (20 %) |
Total | 80 | 15 (18.8 %) | 27 (11.3 %) | 22 (9.2 %) | 6 (2.5 %) | 32 (40 %) |
Signif. difference? | Y | Y | N | Y | ||
p-value | 0.0095 | <0.0001 | 0.3959 | <0.0001 |
Var-associated and non-var-associated groups of PQSs were scored for the four characteristics predicted to be G4-stabilizing: the table shows the number of PQSs in each group showing each characteristic. Differences between the scores for the two groups were assessed by Fisher’s exact test (2-tailed)