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. 2016 Nov 2;16:428. doi: 10.1186/s12906-016-1419-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — VM formation is association with HIF-1α and EMT markers in CRC xenograft tumors. The IHC of CRC xenografts vivo data showed that HCT-116 VM formation was inhibit by YAF. The effect of YAF on HIF-1α and E-cadherin, Claudin-4 as well as Vimentin, in CRC xenograft tumors