Table 3.
Identification of potential RDs for lineage classification in Mtb lineages without existing RD markers
| Lineage | Sample size | RD detected | Performance | ||||
|---|---|---|---|---|---|---|---|
| No. | Start | End | Length (bp) | Sensitivity | Specificity | ||
| Lineage 4.3.4.2.1 | 15 | 1 | 164,942 | 165,740 | 799 | 100 % (15/15) | 100 % (102/102) |
| Lineage 4.6.1.2 | 11 | 1 | 2,902,556 | 2,904,328 | 1,773 | 100 % (11/11) | 97.17 % (103/106) |
| 2 | 2,265,142 | 2,266,241 | 1,100 | 100 % (11/11) | 98.11 % (104/106) | ||
| 3 | 1,190,141 | 1,190,733 | 593 | ||||
| 4 | 2,634,174 | 2,634,542 | 369 | ||||
| 5 | 3,594,343 | 3,594,407 | 65 | ||||
| Lineage 4.6.2.2 | 4 | 1 | 1,897,554 | 1,900,204 | 2,651 | 100 % (4/4) | 99.12 % (112/113) |
| 2 | 3,785,220 | 3,785,638 | 419 | ||||
| 3 | 3,905,337 | 3,905,721 | 385 | ||||
| 4 | 3,742,614 | 3,742,895 | 282 | ||||
| Lineage 4.4.1.1 | 4 | 1 | 2,025,760 | 2,028,437 | 2,678 | 100 % (4/4) | 99.12 % (112/113) |
| 2 | 3,123,673 | 3,125,705 | 2,033 | 100 % (4/4) | 99.12 % (112/113) | ||
| 3 | 3,112,311 | 3,112,459 | 149 | ||||
| 4 | 1,313,135 | 1,313,278 | 144 | ||||
| 5 | 3,377,623 | 3,377,670 | 48 | ||||
Note Bold letters refer to the potential RD markers whose sensitivity and specificity for classification have been assessed. The start and end positions correspond to the genomic positions of Mtb H37Rv genome