Table 2.
List of 25 genes in the core gene set that were differentially expressed in two independent GEO data sets
| Gene symbol | Gene name | Number of interactions | Number of pathways | Mean (SD) log2 expression | p-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Trucker | Dock | Office | ANOVA | PM2.5 | EC | OC | ||||
| GNAQ | Guanine nucleotide binding protein, q polypeptide | 15 | 18 | 5.96 (1.17) | 7.04 (0.91) | 6.15 (1.74) | 0.0004 | 0.1535 | 0.0116 | 0.0017 |
| CTR9 | Ctr9, Paf1/RNA polymerase II complex component | 13 | 7 | 7.01 (0.64) | 7.44 (0.49) | 7.10 (0.61) | 0.0037 | 0.5095 | 6.11E-06 | 5.59E-06 |
| HSP90AA1 | Heat shock protein 90 kDa alpha, class A member 1 | 12 | 0 | 10.24 (0.66) | 10.43 (0.35) | 10.13 (0.74) | 0.1687 | 0.8814 | 1.36E-08 | 0.0353 |
| MLH1 | mutL homolog 1 | 10 | 19 | 8.66 (0.29) | 8.83 (0.21) | 8.65 (0.39) | 0.0184 | 0.0037 | 0.0025 | 0.0547 |
| FNBP4 | Formin binding protein 4 | 10 | 23 | 10.36 (0.49) | 10.86 (0.29) | 10.44 (0.62) | 1.10E-05 | 0.1515 | 0.0063 | 0.0004 |
| ACP1 | Acid phosphatase 1 | 10 | 13 | 8.71 (0.52) | 9.22 (0.28) | 8.69 (0.56) | 3.53E-06 | 0.0107 | 1.95E-06 | 0.0003 |
| MDC1 | Mediator of DNA-damage checkpoint 1 | 10 | 17 | 8.93 (0.49) | 9.32 (0.35) | 8.93 (0.54) | 0.0004 | 0.1663 | 0.0530 | 5.75E-05 |
| LEF1 | Lymphoid enhancer-binding factor 1 | 9 | 42 | 11.17 (0.45) | 11.41 (0.32) | 11.00 (0.46) | 0.0006 | 0.0291 | 0.0096 | 0.0001 |
| LPIN1 | Lipin 1 | 9 | 28 | 9.69 (0.52) | 10.17 (0.36) | 9.78 (0.65) | 9.96E-05 | 0.1880 | 0.0006 | 0.0005 |
| RBM5 | RNA binding motif protein 5 | 9 | 15 | 11.73 (0.30) | 12.02 (0.22) | 11.77 (0.39) | 4.36E-05 | 0.0333 | 0.0101 | 0.0008 |
| MAN1A1 | Mannosidase, alpha, class 1A, Member 1 | 8 | 4 | 5.26 (0.97) | 5.85 (0.75) | 5.46 (1.06) | 0.0138 | 0.2408 | 2.35E-05 | 2.06E-06 |
| ZFP161 | Zinc finger protein 161 | 8 | 17 | 8.08 (0.51) | 8.28 (0.26) | 8.05 (0.60) | 0.1081 | 0.1419 | 0.0046 | 0.0030 |
| HSPA8 | Heat shock 70 kDa protein 8 | 7 | 21 | 12.49 (0.24) | 12.66 (0.17) | 12.47 (0.32) | 0.0031 | 0.0096 | 1.81E-05 | 0.0081 |
| PRIM1 | Primase 1 | 6 | 39 | 7.70 (0.40) | 7.88 (0.24) | 7.56 (0.44) | 0.0045 | 0.0632 | 3.47E-05 | 0.1771 |
| STAT1 | Signal transducer and activator of transcription 1 | 6 | 0 | 11.86 (0.60) | 11.49 (0.34) | 11.79 (0.51) | 0.0066 | 0.6718 | 0.0821 | 2.14E-06 |
| CITED2 | Cbp/p300-interacting transactivator 2 | 4 | 19 | 9.62 (0.48) | 9.84 (0.38) | 9.70 (0.42) | 0.0728 | 0.0201 | 0.0069 | 0.0112 |
| APLP2 | Amyloid beta precursor-like protein 2 | 4 | 0 | 6.01 (0.98) | 5.84 (0.65) | 6.21 (0.77) | 0.2322 | 5.65E-08 | 0.3388 | 0.8264 |
| DDX3Y | DEAD box polypeptide 3, Y-linked | 4 | 16 | 2.48 (1.72) | 2.84 (1.48) | 2.70 (1.77) | 0.5375 | 0.0574 | 0.0386 | 0.0191 |
| HLA-DMA | Major histocompatibility complex, class II, DM alpha | 4 | 0 | 12.50 (0.46) | 12.18 (0.44) | 12.45 (0.54) | 0.0069 | 0.7922 | 7.36E-06 | 9.93E-06 |
| DOCK9 | Dedicator of cytokinesis 9 | 2 | 18 | 2.95 (1.48) | 4.37 (1.19) | 3.25 (1.82) | 7.74E-05 | 0.1116 | 0.0001 | 0.0002 |
| EML3 | Echinoderm microtubule associated protein like 3 | 2 | 17 | 11.70 (0.39) | 11.56 (0.33) | 11.57 (0.34) | 0.0787 | 0.0175 | 0.0133 | 0.0006 |
| GPBAR1 | G protein-coupled bile acid receptor 1 | 2 | 0 | 10.24 (0.60) | 9.91 (0.48) | 10.31 (0.81) | 0.0227 | 0.9312 | 0.0002 | 7.27E-07 |
| USP34 | Ubiquitin specific peptidase 34 | 2 | 22 | 8.49 (0.39) | 8.89 (0.31) | 8.55 (0.58) | 5.32E-05 | 0.0366 | 0.0095 | 0.0077 |
| ZNF589 | Zinc finger protein 589 | 1 | 0 | 9.00 (0.49) | 9.02 (0.36) | 8.66 (0.40) | 0.0004 | 3.60E-08 | 0.2132 | 0.5830 |
| CTAGE5 | CTAGE family, member 5 pseudogene | 0 | 0 | 3.26 (1.05) | 4.10 (0.99) | 3.68 (1.27) | 0.0008 | 0.5163 | 0.5885 | 0.0008 |