Table 3.

The Relationship of Inflammation with Physical Function with and without Adjusting for White Matter Hyperintensities (WMH)

	Walking Speed (cm/s)		Mobility Difficulty
	β, p-value		OR, p-value
Inflammatory Marker	(95% CI)		(95% CI)
	m1: Without WMH n=1960	m2: With WMH n=1660	m1: Without WMH n=1961	m2: With WMH n=1958
sTNFR1	−2.743 p<0.001	−2.524 p<0.001	1.360 p=0.001	1.320 p=0.007
	(−3.95,−1.53)	(−3.83,−1.22)	(1.13,1.63)	(1.08,1.61)
sTNFR2	−1.230 p=0.030	−1.118 p=0.058	1.247 p=0.005	1.223 p=0.014
	(−2.34,−0.12)	(−2.27,0.04)	(1.07,1.45)	(1.04,1.44)
CRP	−1.946 p=0.001	−2.460 p<0.001	1.219 p=0.005	1.200 p=0.018
	(−3.08,−0.81)	(−3.72,−1.20)	(1.06,1.40)	(1.03,1.40)
IL-6	−1.245 p=0.033	−1.399 p=0.034	1.179 p=0.021	1.227 p=0.011
	(−2.39,−0.10)	(−2.69,−0.11)	(1.02,1.36)	(1.05,1.44)

m1: Model 1, Adjusted for education, alcohol, exercise, BMI, HTN, DM, CHD, and MMSE, race-site and interactions between race and age, sex, smoking, and ABI.

m2: Model 2, Adjusted for variables in “m1” plus WMH

Abbreviations: sTNFR1 = soluble tumor necrosis factor receptor 1; sTNFR2 = soluble tumor necrosis factor receptor 2; CRP = C-reactive protein; IL-6 = interleukin-6; WMH = white matter hyperintensities