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. Author manuscript; available in PMC: 2016 Nov 3.
Published in final edited form as: Lancet Oncol. 2016 Mar 18;17(5):590–599. doi: 10.1016/S1470-2045(15)00621-X

Table 4.

Comparative risk of lung cancer diagnosis by screen result

Univariate model*
 Multivariate model†
HR (95% CI) p value HR (95% CI) p value
Negative T0 vs positive T0 0·25 (0·22–0·29) <0·0001 0·27 (0·24–0·31) <0·0001
Negative T0 and T1 vs negative T0 and positive T1 0·20 (0·16–0·24) <0·0001 0·22 (0·18–0·27) <0·0001
Negative T0, T1, and T2 vs negative T0 and subsequent positive 0·12 (0·10–0·15) <0·0001 0·13 (0·11–0·17) <0·0001
*

Cox proportional hazards model predicting time from T0 screen to lung cancer diagnosis.

†

Cox proportional hazards model predicting time from T0 screen to lung cancer diagnosis that includes the following additional baseline parameters: age, sex, race, smoking pack-years, emphysema on T0 screen, history of COPD, and family history of lung cancer. HR=hazard ratio. T0=baseline prevalence screen. T1=first annual screen. T2=second annual screen.