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. 2016 Nov 3;14:311. doi: 10.1186/s12967-016-1067-6

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of pre-existing periodontitis on weight changes, arthritis disease severity and α-1-AGP levels. a Mean changes in weight (grams ± SE) in arthritis rats with and without periodontitis throughout the experimental period of 15 weeks. b Mean arthritis disease severity score (±SE) of front and hind paws in arthritis rats with and without periodontitis, up to 7 weeks after pristane injection. c Mean plasma concentrations (μg/ml ± SE) of α-1-AGP in arthritis rats with and without periodontitis throughout the experimental period of 15 weeks. The results are presented as mean values (±SE) for the groups PA (n = 9) and A (n = 12) at different time-points throughout the experiment. Gray line indicates time point of pristane injection. PIA pristane-induced arthritis, PA rats with experimental periodontitis and PIA, A rats with PIA without periodontitis