Table 5.

Effect of supplementing AGP, feed enzymes (ENZ) or yeast extract (YE) without or with ENZ on ileum, jejunum and duodenum histomorphology of weaned piglets after 96 h of challenge with E. coli LPS

		LPS treatmentsc						Factoriald			Contrast
Itema	NCCb	AGP	CC	YE	ENZ	YE + ENZ	SEM	Main effect YE	Main effect ENZ	YE × ENZ	NCC vs CC	AGP vs CC	AGP vs YE	AGP vs ENZ	AGP vs YE + ENZ
Duodenum, μm
Villus height	532	493	410	480	520	538	24.7	0.098	0.004	NS	0.002	0.03	NS	NS	NS
Crypt depth	322	308	277	305	314	316	13.1	NS	NS	NS	0.02	NS	NS	NS	NS
VH:CD	1.65	1.61	1.50	1.58	1.68	1.70	0.088	NS	NS	NS	NS	NS	NS	NS	NS
Jejunum, μm
Villus height	465	400	293	385	385	412	26.3	0.049	0.047	NS	<.0001	0.01	NS	NS	NS
Crypt depth	277	269	255	275	282	273	13.2	NS	NS	NS	NS	NS	NS	NS	NS
VH:CD	1.70	1.50	1.15	1.40	1.37	1.51	0.092	0.03	0.07	NS	0.0003	0.01	NS	NS	NS
Ileum, μm
Villus height	329	323	272	294	308	306	18.8	NS	NS	NS	0.04	0.07	NS	NS	NS
Crypt depth	265	259	244	233	268	249	13.6	NS	NS	NS	NS	NS	NS	NS	NS
VH:CD	1.24	1.26	1.11	1.26	1.17	1.23	0.067	NS	NS	NS	NS	NS	NS	NS	NS

^a VH:CD villus height/crypt depth; means are averages of at least 15 well oriented villus and crypt columns

^b NCC non-challenged control pigs that were fed the basal diet and injected with sterile saline on d 7

^cPigs fed the basal diet without any additive (CC challenged control) or with AGP, YE, ENZ or ENZ + YE and injected with E. coli LPS on d 7

^d P-value for LPS + ENZ × LPS + YE interaction (CC, YE, ENZ and ENZ + YE)