Figure 1.

PKC binding affinity of bryostatin 1 and 7, selected bryostatin analogues and neristatin 1.^a

^aBinding affinity to PKCα. See reference 7h for PKCα binding affinity of bryostatin 1 and bryostatin 7. ^bCompounds I-V prepared by Wender⁹ were reported to function similarly to bryostatin 1 with regard to the pattern of PKCδ-GFP translocation induced in rat basophilic leukemia cells.^9h,i,k Binding affinity refers to a mixture of rat brain PKC isozymes. The initially reported binding affinity of I (0,25 nM) has been revised.^{9o c}For the indicated Merle bryologs prepared by Keck,¹⁰ PMA-like vs bryostatin-like biology was established via U937 attachment and inhibition of proliferation assays.