Table 5.

Multivariable Cox regression models for death

Variable	MODEL 1	MODEL 2	MODEL 3	MODEL 4
	Clinical AIC=1772.0	Clinical + Classification AIC=1757.7	MODEL 2 + SCysC AIC=1718.7	MODEL 2 + pNGAL AIC=1735.2
Age	1.0 (1.0 – 1.1)	1.1 (1.0 – 1.1)	1.0 (1.0 – 1.1)	1.0 (1.0 – 1.1)
(a)Sex	0.6 (0.5 – 0.9)	0.6 (0.4 – 0.9)	0.6 (0.4 – 0.8)	0.6 (0.4 – 0.9)
CLD	1.7 (1.0 – 2.7)	1.6 (1.0 – 2.5)	1.4 (0.9 – 2.4)	1.5 (0.9 – 2.5)
(b)CCI	2.2 (1.5 – 3.1)	2.2 (1.6 – 3.2)	1.9 (1.3 – 2.7)	2.0 (1.4 – 2.9)
Cancer	3.3 (2.1 – 5.1)	3.7 (2.4 – 5.7)	4.5 (2.8 – 7.0)	4.2 (2.7 – 6.5)
(c)Classification
AKI		1.9 (1.3 – 2.8)	1.4 (0.9 – 2.3)	1.8 (1.1 – 2.7)
TAz		1.1 (0.7 – 1.7)	1.0 (0.7 – 1.6)	1.1 (0.7 – 1.7)
sCKD		0.3 (0.1 – 1.1)	0.2 (0.1 – 0.8)	0.3 (0.1 – 0.9)
SCys			1.6 (1.1 – 2.3)
(d)pNGAL				1.2 (0.8 – 1.8)

Results are expressed as hazard ratios (95% confidence interval); SCysC, serum cystatin C; pNGAL, plasma NGAL; AIC, Akaike’s Information Criterion; AKI, acute kidney injury; TAz, transient azotemia; sCKD, stable chronic kidney disease; CLD, Chronic Liver Disease; CCI, Comorbidity Charlson Index score;

^(a)reference category: male;

^(b)reference category: CCI≤3;

^(c)reference category: NF (normal function);

^(d)reference category: pNGAL ≤ 133 ng/mL;

Model 1: Sex p=0.015, CLD p=0.035 and p<0.001 for the remaining variables; Model 2: sex p=0.009, CLD p=0.076, Taz p=0.551, sCKD p=0.062, p<0.001 for the remaining variables; Model 3: sex p=0.002, CLD p=0.149, AKI p=0.150, Taz p=0.935, sCKD p=0.023, p<0.001 for the remaining variables; Model 4: sex p=0.006, CLD p=0.091, AKI p=0.010, Taz p=0.720, sCKD p=0.038, NGAL p=0.269, p<0.001 for the remaining variables.