Table 1.

Concentrations (mmol/kg wet brain) and ratios (Cho/Cre) in frontal and temporal lobes in healthy volunteers and in patients chronically treated with valproate (Study #2)

			Choline (Cho)		Creatine (Cre)		Cho/Cre
			Frontal	Temporal	Frontal	Temporal	Frontal	Temporal
Healthy Controls	Age	Sex
1	50	M	3.51	2.95	6.67	8.53	0.53	0.35
2	45	M	2.19	3.03	10.1	9.11	0.22	0.33
3	43	F	3.01	2.31	9.97	9.52	0.30	0.24
4	39	M	2.11	2.72	7.94	7.60	0.27	0.24
5	37	F	2.47	2.34	9.98	9.89	0.25	0.24
6	36	F	1.91	1.76	8.28	8.19	0.23	0.22
7	35	M	1.76	2.36	7.93	8.36	0.22	0.28
8	32	F	1.88	1.51	9.56	9.56	0.2	0.16
9	32	M	1.94	2.14	7.04	7.79	0.28	0.28
10	30	F	1.82	2.52	7.8	8.63	0.23	0.29
11	28	M	1.72	2.23	7.16	8.51	0.24	0.26
Mean	37.00		2.21	2.35	8.40	8.70	0.27	0.26
Valproate Treated Patients
1	58	F	2.72	2.1	9.16	10.13	0.30	0.21
2	50	M	2.61	3.42	8.17	10.53	0.32	0.33
3	49	F	2.03	1.79	8.56	7.48	0.24	0.24
4	48	F	2.44	1.88	9.93	8.19	0.25	0.23
5	36	M	2.60	2.53	7.84	7.51	0.33	0.34
6	35	F	2.07	2.77	9.26	10.39	0.22	0.27
7	35	F	2.78	1.89	8.35	9.79	0.33	0.19
8	34	F	1.76	2.93	7.26	8.01	0.24	0.37
9	34	F	2.43	2.27	7.75	7.23	0.31	0.31
Mean	42.11		2.38	2.40	8.48	8.81	0.28	0.28