Table 2.
A comparison of physiological and behavioural markers across new mouse mothers treated with 667-COUMATE and vehicle (CVCV), with 667-COUMATE and 0.3 mg/kg ziprasidone (CZCZ0.3) or with 667-COUMATE and 1.0 mg/kg ziprasidone (CZCZ1.0). *significantly different from other two groups (p < 0.05).
| Measure of interest | CVCV | CZCZ0.3 | CZCZ1.0 | Statistical significance |
|---|---|---|---|---|
| Litter measures | ||||
| Initial litter size | 7.0 (95%CI: 6.0–8.0) | 6.0 (95%CI: 5.0–7.0) | 6.5 (95% CI: 6.0–8.0) | p = 0.26 |
| Number of pups found dead per mother across course of experiment | 0 (95%CI: 0–0) | 0 (95%CI: 0–2) | 0 (95%CI: 0–1) | p = 0.54 |
| Elevated plus maze measures | ||||
| Rearing | 0.5 (95%CI: 0–12.5) | 2.5 (95%CI: 0–14) | 0 (0–0) | p = 0.20 |
| Latency to first open arm entry (s) | 7.8 (95%CI: 4.5–15.4) | 8.7 (95%CI: 5.0-12.8) | 11.1 (95%CI: 6.0-26.4) | p = 0.51 |
| Closed arm entries | 28 ± 3* | 20 ± 2 | 12 ± 3 | F[2,37] = 9.44, p < 0.001 |
| Locomotor activity measures | ||||
| Total infra-red beam breaks in 1hr | 1837 ± 182, | 1536 ± 172 | 1294 ± 233 | F[2,37] = 1.75, p = 0.19 |