Table 3.

Rate of Severe Hypoglycemia and Its Relation to Different Well-Known Risk Factors for Severe Hypoglycemia in 98 Patients With Type 1 Diabetes.

A. The relation according to state of hypoglycemia awareness
Severe hypoglycemia	State of hypoglycemia awareness		Relative ratea of severe hypoglycemia (95% confidence interval)	P
Baseline	Baseline	Impaired	3.6 (1.7-7.6)	.001
		Unaware	10.9 (4.4-27.3)	<.0001
Follow-upb	Baseline	Impaired	1.4 (0.5-3.7)	.52
		Unaware	3.1 (0.9-10.5)	.07
Follow-upb	Follow-up	Impaired	3.3 (0.9-12.2)	.08
		Unaware	10.3 (2.3-44.3)	.002
B. The relation according to other risk factors for severe hypoglycemia
	Severe hypoglycemia		Relative ratec of severe hypoglycemia (95% confidence interval)	P
C-peptide status
Baseline	Baseline		2.6 (1.5-4.6)	.001
Baseline	Follow-up		1.0 (0.4-2.4)	.96
Follow-up	Follow-up		1.9 (0.2-16.3)	.55
Duration of diabetes
Baseline	Baseline		3.2 (1.2-12.5)	.096
Baseline	Follow-up		1.5 (0.5-4.4)	.47
Follow-up	Follow-up		1.9 (0.5-7.0)	.34
HbA1c
Baseline	Baseline		0.8 (0.5-1.3)	.40
Baseline	Follow-up		1.0 (0.7-1.4)	.81
Follow-up	Follow-up		0.9 (0.6-1.5)	.71

The relation is assessed by univariate analyses.

^aState of hypoglycemia awareness as compared to normal awareness.

^b1 patient is excluded as described in the text.

^cC-peptide status: C-peptide-negative patients as compared to patients with detectable C-peptide levels, duration of diabetes: per 10 year’s increment, HbA1c: per 1% increment.