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. Author manuscript; available in PMC: 2016 Nov 6.
Published in final edited form as: Science. 2016 Mar 31;352(6286):712–716. doi: 10.1126/science.aad8373

Fig. 2. Oligomeric Aβ increases C1q and microglial phagocytic activity.

Fig. 2

(A and B) Soluble Aβ oligomers in WT mice led to elevation of C1q (green) (A) and a higher % PSD95 (red) colocalization with C1q vs. monomers (B). (C and D) oAβ induced high levels of CD68 (green) immunoreactivity in Iba1-positive (red) microglia in WT mice (C), but not in those of C1qa KO mice (D). Both had negligible changes in morphology. See Fig. S10. Scale bar = 10 (A), 5 (B) or 20 (C) μm. Means ± SEM; n = 3-5 mice per treatment group per genotype. *P < 0.05 using two-tailed t-test (B) or *P < 0.05, **P < 0.01 vs. control-treated or ##P < 0.01 vs. Aβ monomer-treated using two-way ANOVA followed by Bonferroni posttest (C).