Table 3.
Univariate and Multivariate Cox Regression Analysis of PFS (N = 50)
| Variables | HR (95% CI) | P Value | Adjusted HR (95% CI) | P Value |
|---|---|---|---|---|
| Age⁎ | 1.01 (0.97-1.05) | .596 | ||
| Sex | ||||
| Female | 0.65 (0.35-1.22) | .180 | ||
| Male | 1.00 | |||
| Histology | ||||
| Adenocarcinoma | 0.95 (0.43-2.07) | .892 | ||
| Squamous cell | 1.00 | |||
| Smoking | ||||
| Never or former† | 0.99 (0.49-1.99) | .978 | ||
| Current | 1.00 | |||
| PS, ECOG | ||||
| 0-1 | 1.08 (0.45-2.57) | .872 | ||
| 2 | 1.00 | |||
| Stage | ||||
| IV | 0.40 (0.12-1.37) | .144 | ||
| III | 1.00 | |||
| Brain metastases | ||||
| Yes | 3.31 (1.34-8.21) | .010 | 34.54 (2.75-433.56) | .006 |
| No | 1.00 | 1.00 | ||
| Erlotinib treatment | ||||
| 1st or 2nd line | 0.85 (0.40-1.80) | .668 | ||
| 3rd line | 1.00 | |||
| %∆TLG⁎ | 1.02 (1.01-1.03) | .002 | 1.02 (1.00-1.03) | .045 |
| %∆SULpeak⁎ | 1.01 (1.00-1.02) | .100 | ||
| %∆cfDNA⁎ | 1.001 (1.00-1.001) | .004 | 1.001 (1.00-1.002) | .017 |
⁎
Evaluated as a continuous variable.
†
Former smoker was defined as having stopped smoking at time of diagnosis.