Table 4.
Univariate and Multivariate Cox Regression Analysis of OS (N = 50)
| Variables | HR (95% CI) | P Value | Adjusted HR (95% CI) | P Value |
|---|---|---|---|---|
| Age⁎ | 1.00 (0.97-1.04) | .845 | ||
| Sex | ||||
| Female | 0.63 (0.33-1.22) | .169 | ||
| Male | 1.00 | |||
| Histology | ||||
| Adenocarcinoma | 0.99 (0.43-2.26) | .977 | ||
| Squamous cell | 1.00 | |||
| Smoking | ||||
| Never or former† | 1.46 (0.69-3.07) | .322 | ||
| Current | 1.00 | |||
| PS, ECOG | ||||
| 0-1 | 0.59 (0.28-1.26) | .177 | ||
| 2 | 1.00 | |||
| Stage | ||||
| IV | 0.55 (0.19-1.58) | .267 | ||
| III | 1.00 | |||
| Brain metastases | ||||
| Yes | 3.47 (1.45-8.11) | .004 | 17.00 (2.94-98.44) | .002 |
| No | 1.00 | 1.00 | ||
| Erlotinib treatment | ||||
| 1st or 2nd line | 1.19 (0.52-2.72) | .676 | ||
| 3rd line | 1.00 | |||
| %∆TLG⁎ | 1.02 (1.00-1.03) | .009 | 1.01 (1.00-1.02) | .178 |
| %∆SULpeak⁎ | 1.00 (0.99-1.02) | .716 | ||
| %∆cfDNA⁎ | 1.001 (1.00-1.001) | .009 | 1.001 (1.00-1.001) | .043 |
⁎
Evaluated as a continuous variable.
†
Former smoker was defined as having stopped smoking at time of diagnosis.