Table 2.
Biochemical characteristics of the study populationa
| All (n = 142) | Leptin | P-value | ||
|---|---|---|---|---|
| <11.42 ng/mL (n = 71) | ≥11.42 ng/mL (n = 71) | |||
| GFRb, mL/min/1.73 m2 | 35 ± 19 | 40.42 ± 20.71 | 30.05 ± 15.76 | 0.016 |
| Leptin, ng/mL | 29.58 ± 36.1 (11.42) | 2.79 ± 2.98 (1.82) | 56.38 ± 34.15 (43.57) | NA |
| Total adiponectin, µg/mL | 10.56 ± 5.91 | 11.57 ± 6.42 | 9.38 ± 5.14 | 0.031 |
| HMW adiponectin, µg/mL | 5.50 ± 4.24 | 6.29 ± 4.81 | 4.72 ± 3.46 | 0.027 |
| Insulin, µU/mL | 29.3 ± 23.5 | 20.6 ± 17.8 | 38.1 ± 25.3 | 0.001 |
| Triglycerides, mMol/L | 2.03 ± 1.3 | 1.57 ± 0.8 | 2.46 ± 1.5 | <0.0001 |
| Total cholesterol, mMol/L | 4.9 ± 1.1 | 4.60 ± 1.15 | 5.12 ± 1.11 | 0.009 |
| LDL cholesterol, mMol/L | 2.62 ± 0.9 | 2.46 ± 0.8 | 2.78 ± 0.9 | 0.04 |
| CRP, mg/L | 11.2 ± 24 (3.5) | 9.5 ± 19.3 (2.12) | 12.9 ± 27.8 (4.26) | 0.01 |
| Interleukin-6, pg/mL | 5.25 ± 7.9 | 4.18 ± 4.21 | 6.24 ± 10.11 | 0.183 |
| Calcium, mMol/L | 2.29 ± 0.18 | 2.26 ± 0.19 | 2.31 ± 0.17 | 0.101 |
| Phosphate, mMol/L | 1.28 ± 0.46 | 1.33 ± 0.53 | 1.24 ± 0.37 | 0.212 |
| Intact PTH, pg/mL | 137 ± 137 (85) | 116 ± 138 (78) | 159 ± 135 (121) | 0.01 |
| Albumin, g/L | 37.4 ± 6.4 | 36.9 ± 7.2 | 37.9 ± 5.5 | 0.506 |
| Haemoglobin, g/dL | 12.1 ± 1.7 | 12.24 ± 1.81 | 11.94 ± 1.66 | 0.48 |
aData are expressed as the mean ± SD and, for variables with a non-Gaussian distribution, the median.
PTH, parathyroid hormone; CRP, C-reactive protein; GFR, glomerular filtration rate; HMW, high-molecular weight; LDL, low density lipoprotein.
bCalculated for patients at CKD stages 2–5 (n = 96).