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. 2016 Oct 28;9(6):489–497. doi: 10.1016/j.tranon.2016.09.005

Figure 3.

Figure 3

HOTAIR relieves the inhibitory effects of miR-1 on ESCC cells. (A and B) CCK8 assays show that the increase of miR-1 level significantly reduces cell viability in KYSE30 and KYSE510 cells, and the treatment of miR-1 + pcDNA-HOTAIR abolishes the inhibitory effect induced by miR-1. (C and D) Flow cytometry analysis show that the increase of miR-1 level induces the G1 cell cycle arrest in KYSE30 and KYSE510 cells; inversely, the treatment of miR-1 + pcDNA-HOTAIR relieves the G1 cell cycle arrest induced by miR-1. *P < .05 and **P < .01.