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Cytotoxic effect of single or combinatory treatment of CDDP, HPV16 E6/E7-CRISPR/Cas9 on SiHa cells. (A) Compared with negative control cells, HPV16 E6/E7-CRISPR/Cas9 exerted most significant cytotoxic effect on SiHa cells. (B) The cytotoxicity of CDDP was strengthened when combined with HPV16 E6/E7-CRISPR/Cas9. Data represent the mean of three impendent experiments ± SE. The asterisk represents statistically significant difference compared with negative control (*P < .05; **P < .01).
