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. 2016 Oct 28;9(6):498–504. doi: 10.1016/j.tranon.2016.10.002

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Synergistic inhibition of CDDP and HPV16 E6/E7-CRISPR/Cas9 co-treatment on xenograft tumor growth. (A) Mice were killed at day 21 after first injection, tumor were removed and photographed.; (B) The volumes of xenograft tumors were measured and plotted at indicated time points after treatment.(C-D) The total RNA was isolated from tumortissues, and the expression of E6 and E7were detected by real-time RT-PCR. Data represent the mean of three impendent experiments ± SD. The asterisk represents statistically significant difference compared with negative control (*P < .05; **P < .01).