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. 2016 Oct 28;9(6):498–504. doi: 10.1016/j.tranon.2016.10.002

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Proapoptotic effect of CDDP combined with HPV16 E6/E7-CRISPR/Cas9 in xenograft tumor tissues. (A) Western blot results showed that CDDP and HPV16 E6/E7-CRISPR/Cas9 co-treated xenograft tumor tissues presented the most significant increase of Bax and P53 and decrease of Bcl-2. (B) Apoptosis assay by flow cytometry using Annexin V and PI staining showed that CDDP and HPV16 E6/E7-CRISPR/Cas9 cotreatment produced a significant increase in percentage of apoptotic cells. (1, Control-treated; 2 CDDP-treated; 3, E6 + E7 CRISPR/Cas9-treated; 4, E6 + E7 + CDDP-treated).