Table 1.

Effect of NAC, amlodipine, lisinopril or allopurinol administration on markers of liver injury.

Parameters	Control groupA	Acetaminophen groupB	NAC treatment groupC	Amlodipine treatment groupD	Lisinopril treatment groupE	Allopurinol treatment groupF
Serum ALT (U/L)	45.3 ± 2.68	117.8 ± 18.53a	65.7 ± 5.08b	84.1 ± 4.39ab	61.8 ± 9.23b	76.8 ± 5.09b
Serum AST (U/L)	155.3 ± 9.98	503.0 ± 76.78a	218.0 ± 3.69b	303.0 ± 7.63ab	225.5 ± 21.45b	307.8 ± 10.79ab

Data are expressed as mean of 6–8 rats ± SEM. Multiple comparisons were done using one-way ANOVA test followed by Student–Newman–Keuls as post hoc test.

ALT: Alanine transaminase, ANOVA: Analysis of variance, AST: Aspartate transaminase, NAC: N-acetylcysteine, SEM: Standard error of the mean.

^AControl group receiving only vehicles.

^BAcetaminophen group, subjected to a single oral dose of acetaminophen (750 mg/kg).

^CTest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where NAC was given in a dose of 300 mg/kg/day.

^DTest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where amlodipine was given in a dose of 10 mg/kg/day.

^ETest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where lisinopril was given in a dose of 20 mg/kg/day.

^FTest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where allopurinol was given in a dose of 50 mg/kg/day.

^aSignificantly different from control group.

^bSignificantly different from acetaminophen group at p < 0.05.