Table 2.

Effect of NAC, amlodipine, lisinopril or allopurinol administration on markers of oxidative stress.

Parameters	Control groupA	Acetaminophen groupB	NAC treatment groupC	Amlodipine treatment groupD	Lisinopril treatment groupE	Allopurinol treatment groupF
Hepatic TBARS (nmol/g)	24.2 ± 3.20	139.1 ± 7.21a	70.6 ± 5.91ab	67.3 ± 6.85ab	61.9 ± 4.15ab	63.5 ± 5.68ab
Hepatic GSH (μmol/g)	394.6 ± 24.47	135.2 ± 1.98a	242.0 ± 9.54ab	195.5 ± 5.58abc	215.8 ± 2.83ab	240.5 ± 7.43ab
Hepatic CAT (U/mg protein)	0.091 ± 0.0078	0.004 ± 0.0017a	0.046 ± 0.0177ab	0.041 ± 0.0057ab	0.044 ± 0.0076ab	0.038 ± 0.0036ab

Data are expressed as mean of 6–8 rats ± SEM. Multiple comparisons were done using one-way ANOVA test followed by Student–Newman–Keuls as post hoc test.

ANOVA: Analysis of variance, CAT: Catalase, GSH: Glutathione reduced, NAC: N-acetylcysteine, SEM: Standard error of the mean, TBARS: Thiobarbituric acid reactive substances.

^AControl group receiving only vehicles.

^BAcetaminophen group, subjected to a single oral dose of acetaminophen (750 mg/kg).

^CTest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where NAC was given in a dose of 300 mg/kg/day.

^DTest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where amlodipine was given in a dose of 10 mg/kg/day.

^ETest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where lisinopril was given in a dose of 20 mg/kg/day.

^FTest agents were given orally on a daily basis for 14 consecutive days prior to acetaminophen dose, where allopurinol was given in a dose of 50 mg/kg/day.

^aSignificantly different from control group.

^bSignificantly different from acetaminophen group.

^cSignificantly different from standard treatment (NAC) group at p < 0.05.