Table 1.
Pharmacodynamic parameters obtained after subcutaneous administration of tramadol (17.8 mg/kg), metamizol (177.8 mg/kg) and the combination of metamizol and tramadol under acute and chronic administrations (3 times/day/4 days).
| Treatment | Global efficacy ABCe (%h) | Tmax (h) | Emax (%IF) | E4h (%IF) |
|---|---|---|---|---|
| Acute administration | ||||
| TRA 17.8 | 18.33 ± 1.6 | 1.00 | 14.00 ± 1.3 | 0.83 ± 0.7 |
| MET 177.8 | 89.95 ± 17.2 | 0.75 | 59.56 ± 11.6 | 7.00 ± 6.2 |
| MET+TRA | 239.17 ± 26.7⁎ | 1.00 | 85.56 ± 7.9 | 34.69 ± 5.9 |
| Chronic administration (3 times/day/4 days) | ||||
| TRA 17.8 | 11.90 ± 2.0# | 0.50 | 14.00 ± 2.7 | 0.00 ± 0.0 |
| MET 177.8 | 86.70 ± 5.6 | 0.50 | 52.33 ± 6.6 | 0.83 ± 0.6# |
| MET+TRA | 112.00 ± 13.2# | 0.75 | 66.33 ± 5.8# | 5.88 ± 3.8# |
⁎
P ⩽ 0.05 with respect to the theoretical sum of the individual effects.
#
P ⩽ 0.05 with respect to the acute treatment.