Table 1.
Univariate analysis of prognostic factors associated with 5-year disease free survival of 82 patients with large hepatocellular carcinoma who underwent hepatic resection
| Variables | No of patients | Median DFS (months) | No of recurrence | P value |
|---|---|---|---|---|
| Gender | 0.923 | |||
| Male/female | 73/9 | 35/37 | 44/6 | |
| Age (years) | 0.641 | |||
| ≥60/<60 | 22/60 | 33/37 | 13/37 | |
| Tumor size (cm) | 0.037 | |||
| >10/≤10 | 19/63 | 22/40 | 11/39 | |
| Hepatitis status | 0.870 | |||
| HBsAg (+)/(−) | 66/15 | 36/37 | 40/9 | |
| Liver cirrhosis | 0.862 | |||
| Present/absent | 65/17 | 35/34 | 38/12 | |
| AFP (ug/L) | 0.024 | |||
| ≥400/<400 | 35/47 | 27/42 | 27/23 | |
| HR type | 0.735 | |||
| Major/minor | 26/56 | 34/36 | 16/34 | |
| Vascular clamping | 0.832 | |||
| Yes/no | 71/11 | 36/34 | 45/5 | |
| Perioperative transfusions | 0.857 | |||
| Yes/no | 46/36 | 36/35 | 25/25 | |
| Number of tumor | 0.074 | |||
| Solitary/multiple | 68/14 | 38/22 | 38/12 | |
| Tumor capsule | 0.006 | |||
| Present/absent | 48/34 | 44/24 | 24/26 | |
| Microvascular invasion | 0.047 | |||
| Present/absent | 19/63 | 23/39 | 12/38 | |
| Grade of differentiation | 0.003 | |||
| Poor or moderate | 70 | 31 | 47 | |
| Well | 12 | 60 | 3 | |
| Spontaneous tumor rupture | 0.029 | |||
| Present/absent | 12/70 | 17/39 | 9/41 | |
| Complications | 0.677 | |||
| Present/absent | 38/44 | 34/37 | 23/27 |
HBsAg, hepatitis B virus surface antigen; AFP, α-fetoprotein; HR, hepatic resection.