Table 2.

Predictive factors for overall survival in gallbladder cancer

	Univariate analysis		Multivariate analysis
	p-value	Hazard ratio	p-value	Hazard ratio
Neutrophil-lymphocyte ratio ≥5	<0.001	2.08 [1.35, 3.21]	0.002	3.52 [1.58, 7.85]
Dyspnea	0.05	2.32 [1.00, 5.37]	0.009	4.48 [1.45, 14.77]
Severe COPD	0.08	2.44 {0.88, 6.73]
Age	0.09	1.02 [1.00, 1.03]
White blood cell count	0.07	1.04 [1.00, 1.09]
Preoperative peak bilirubin	<0.001	1.09 [1.05, 1.13]	<0.001	1.12 [1.05, 1.20]
Last bilirubin	<0.001	1.10 [1.03, 1.19]
Albumin	<0.001	0.56 [0.42, 0.74]
INR	0.01	3.09 [1.33, 7.19]
CA 19-9	<0.001	1.00 [1.00, 1.00]
Platelet-lymphocyte ratio	0.06	0.99 [0.97, 1.00]

Variables, p-values and hazard ratios in bold indicate those which were found to be significant on multivariate analysis.