Table 2.
Cox proportional hazards model
| HR | 95% CI | p | |
|---|---|---|---|
| Morphology (HCC referent) | |||
| Mixed | 1.16 | [1.07, 1.24] | <0.001 |
| ICC | 1.15 | [1.12, 1.18] | <0.001 |
| Age ≥ 65 | 1 | [0.86, 1.15] | 0.95 |
| Race | |||
| White | Referent | ||
| Black | 1.14 | [0.93, 1.39] | 0.21 |
| Other | 0.74 | [0.58, 0.95] | 0.02 |
| Charlson-Deyo Score | |||
| 0 | Referent | ||
| 1 | 1.3 | [1.08, 1.56] | 0.006 |
| 2 | 1.73 | [1.42, 2.12] | <0.001 |
| Tumor Size | |||
| 0–3 cm | Referent | ||
| 3–5 cm | 1.27 | [0.95, 1.70] | 0.11 |
| 5–10 cm | 1.52 | [1.15, 2.01] | <0.001 |
| ≥10 cm | 1.86 | [1.37, 2.54] | <0.001 |
| N1 status | 0.8 | [0.51, 1.27] | 0.35 |
| High grade tumor | 1.21 | [1.00, 1.47] | 0.05 |
| Lymphovascular invasion present | 1.41 | [0.69, 2.87] | 0.34 |
| Stage | |||
| Localized (Stage 0–2) | Referent | ||
| Locally advanced (Stage 3) | 1.5 | [1.20, 1.87] | <0.001 |
| Metastatic (Stage 4) | 1.64 | [1.32, 2.04] | <0.001 |
| Elevated CA 19-9 | 1.33 | [0.76, 2.32] | 0.32 |
| Margins positive | 1.91 | [1.18, 3.09] | 0.009 |
| Did not receive radiation | 1.2 | [0.95, 1.53] | 0.13 |
| Did not receive chemotherapy | 1.67 | [1.44, 1.94] | <0.001 |
| Surgical procedure | |||
| No surgery | Referent | ||
| Local tumor destruction | 0.38 | [0.21, 0.67] | <0.001 |
| Resection | 0.48 | [0.30, 0.77] | 0.002 |
| Transplant | 0.38 | [0.23, 0.63] | <0.001 |