Figure 3.

The putative binding mode of compounds 15 (Panel A), 34 (Panel B), 1 (Panel C) within PDE4D active site. Carbons atoms in 15, 34, 1, are coloured in cyan. The main amino acids residues are shown in sticks, the enzyme is shown in cartoon diagram. The residues forming the M, Q and S pockets displayed in cartoon diagram are coloured orange, pink and green respectively, Zinc and Magnesium ions and the oxygen of the water are represented as spheres and the H‐bonds between each ligand and the active site amino acids are shown in dashed line.