Table 1.
Molecular structure of compounds 1–5
| Compound | R1 | PDE4D IC50 (μM) |
|---|---|---|
| 1 |
|
0.67 |
| 2 |
|
3.48 |
| 3 |
|
3.46 |
| 4 |
|
5.91 |
| 5 |
|
3.42 |
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