Table 2.

Pearson correlation coefficient r between abundances of non-canonical peptides detected by unsupervised proteomic analyses of trypsin-digested human mitochondrial proteomic MS/MS data and abundances of corresponding, previously detected non-canonical RNAs [22], [23]. Correlations are calculated separately for tryptic peptides (carboxyl extremity K or R) and other peptides. Non-canonical transcripts are del-and swinger-transformations of the human mitogenome, the latter translated along codons expanded by 0, 1 and 2 silent nucleotides. P values are one tailed, expecting positive correlations. Fisher's method for combining P values sums the − 2 × log Pi, where i runs from 1 to k. This sum follows a chi-square statistic distribution with 2 × k degrees of freedoms, where k is the number of Ps combined (here k = 4). Bold indicates statistical significance at P < 0.05.

Pearson r	Unbias Tryps		Other
Transformation	r	P	r	P	All
Del	0.358	0.172	0.270	0.241	0.401
Swinger	0.446	0.016	0.171	0.217	0.253
Swinger tetra	0.109	0.310	0.099	0.327	0.143
Swinger penta	0.192	0.190	0.306	0.078	0.186
Combined chi	17.41	0.026	13.24	0.104