Figure 1.
Relative changes in LINE-1 methylation levels in blood samples of balb/c mice treated with guadecitabine. Two months old female female Balb/c nude mice (BALB/cOlaHsd-Foxn1nu)balb/c Huh-7 tumor-bearing mice were injected s.c. with 2 mg/kg of guadecitabine and LINE-1 demethylation levels in whole blood [calculated as (methylation levels at day x – methylation levels at day 0)/(methylation levels day 0 *100)] were assessed at 9 and at 16 d post guadecitabine administration. Results for individual mice are shown. Six out of 8 mice (75%) show a distinct relative LINE-1 demethylation.